Protect Your Brain from the Perils of Polypharmacy

Flickr - Carlos Daniel GomeroDeane Alban, Guest
Waking Times

Prescription drugs cause over 100,000 deaths per year and cause another 1.5 million people to experience side effects so severe they must be hospitalized.

You may be shocked to learn that according to the FDA, adverse drug reactions are now the fourth leading cause of death in the US. (1) This is in part due to the problem of polypharmacy — the taking of several drugs at once that interact in negative and sometimes unexpected ways.

Every medication carries the risk of side effects. When more than one drug at a time is taken, the risks increase exponentially. When you consider that the average 65-year-old takes 5 medications, you can imagine how widespread the problem of polypharmacy is.

Medications and Your Brain

Armon Neel is a board-certified geriatric pharmacist who has devoted his career to guiding health professionals and older adults in the appropriate use of medication. He writes AARP’s Ask the Pharmacist column.

In his book, Are Your Prescriptions Killing You?, he contends that as many as 3 out of 4 Alzheimer’s cases could be caused by drug interactions. This is a stunning indictment!


  • He points out that polypharmacy becomes a greater concern as you grow older. Not only are seniors taking more medications, but the ones they take aren’t handled by the body as well as when they were young.

    Livers and kidneys no longer work as efficiently and have a harder time breaking down and eliminating drugs from the system. This is why some people who have been on a drug for years might suddenly find it causes side effects as they age.

    Many medications can lead to a false-positive diagnosis for dementia or Alzheimer’s. One way common mechanism for this is the reduction in the brain’s level of acetylcholine, the primary neurotransmitter involved with memory and learning. This can lead to symptoms that resemble dementia including mental confusion, delirium, blurred vision, memory loss, and hallucinations.

    Avoid the “Anti-” Drugs

    Here are three of the worst-offending categories of drugs to watch out for:

    • If you take a drug that starts with “anti”, such as antihistamines, antidepressants, antipsychotics, antibiotics, antispasmodics, or antihypertensives, it’s likely that it will affect your acetylcholine levels, and your brain function.

    Statins: The Worst Offender?

    Another frightening side effect of statins is that they can lead to diabetes. Dr. Stephen Sinatra, founder of Heart MD Institute, cites the alarming statistic that 48% of women who take these medications become diabetic.

    We’ve been brainwashed to believe that low cholesterol levels equal a healthy heart but this is now known to not be true.

    Dr. Duane Graveline, a medical doctor and NASA astronaut, wrote an eye-opening account of the dangers of one popular statin drug in Lipitor Thief of Memory. He experienced two bouts of serious memory loss diagnosed as transient global amnesia (TGA). Ultimately, this was traced to his taking Lipitor.

    He is now on another mission — to warn of the perils of cholesterol lowering drugs. You can find over 250 articles on cholesterol, statin drugs, and their side effects on his website SpaceDoc.com.

    Steps to Take If You’re on Multiple Meds

    Fortunately, drug-induced dementia can usually be reversed just by stopping the offending medication. So if you take medications and suspect they might be causing cognitive problems, here are some steps Armon Neel recommends you can take:

        • Take inventory of what you are taking. Write down every medication, dosage, and when you started taking it.
        • Talk to your doctor about what you are taking, how much you are taking, and why you are taking it. If you have more than one physician, have this conversation with each.
        • Ask if there are any non-drug approaches you can take instead. Find out the consequences of stopping any medication. If there are any medications that can be eliminated, discuss a plan for getting off them and follow the plan.
        • You should always get all your medications filled by the same pharmacy. Talk to your pharmacist about your regime to make sure there are no known interactions.
        • Read Are Your Prescriptions Killing You? Reviewers on Amazon call it “a life saver”.

    If you aren’t sure if your medications are causing cognitive problems, we’ve published a list of the top 20 medications that can cause memory loss. Keep in mind that drugs don’t have to be prescription medications to cause problems. Sometimes adding an over-the-counter treatment to the mix can be dangerous as well.

    About the Author

    Deane Alban holds a bachelor’s degree in biology and has taught and written on a wide variety of natural health topics for over 20 years. Her current focus is helping people overcome brain fog, “senior moments”, and other signs of mental decline now, and preventing Alzheimer’s and dementia in the future.

    The human brain is designed to last a lifetime, but modern life takes a greater toll on the brain than most people realize. Deane teaches the best ways to keep your brain healthy and stay mentally sharp for life at her website BeBrainFit.com where you can learn how to make your brain sharp again.

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