The Outrageous Ways Big Pharma Has Bribed Doctors to Shill Drugs

Pharmaceuticals PillsMartha Rosenberg, The Influence
Waking Times

Editor’s Note: This article was originally published by The Influence, and is reprinted here with permission.

At the 2010 meeting of the American Psychiatric Association in New Orleans, a psychiatrist from the East coast shared her anger with me about the recent clamp down on Pharma financial perks to doctors. “They used to wine us and dine us. An SSRI maker flew my entire office to a Caribbean island… but now nothing,” she lamented.

She was right. Before news organizations and the 2010 Physician Financial Transparency Reports (also called the Sunshine Act, part of the Affordable Care Act) reported the outrageous amount of money Pharma was giving doctors to prescribe its new, brand-name drugs, there was almost no limit to what was spent to encourage prescribing.

At another medical conference I attended, soon after, when it was suggested that doctors not accept free meals from Pharma reps because of indebtedness, a doctor asked in all earnestness “but what do we do for lunch?”

He was right. Doctors seldom have to go hungry at lunchtime when Pharma reps are around. Not only do reps reliably bring lunch and free drug samples, until fairly recently they wielded thousand-dollar budgets to send doctors on trips to resorts, golf vacations and to sought after sports events. No wonder the docs saw them.

But by 2010, much of the over-the-top Pharma largesse had ended. Not just because the press and Sunshine Act exposed the huge payments, naming names—but because practically every major drug company from GlaxoSmithKline (GSK), Eli Lilly, Abbott, AstraZeneca, Pfizer and Johnson & Johnson to Amgen, Allergen, Bristol-Myers Squibb, Cephalon, Novartis and Purdue had settled a wrongdoing suit. Both doctors and the public largely viewed Pharma’s safety and effectiveness claims as “bought” by such extravagance.

In fact, by 2010, the number of doctors even willing to see Pharma reps had fallen by almost 20 percent and the number of doctors refusing to see all reps increased by half.  Eight million sales calls were “nearly impossible to complete,” reported ZS Associates.

Still, here are some of the ways Pharma managed to get drugs into your medicine cabinet when the financial excess bestowed on doctors was tolerated:

1) Blue Cross Blue Shield said that Pfizer jetted 5,000 doctors to Caribbean resorts where they enjoyed massages, golf and $2,000 honoraria to try to increase prescriptions for its painkiller Bextra—a drug that proved so unsafe it was withdrawn from the market in 2005 for heart risks.

2) The Justice Department charged that GlaxoSmithKline (GSK) “paid millions to doctors to promote Wellbutrin, approved at the time for depression, for off-label uses by funding meetings, sometimes at lavish resorts,” according to CBS News. Off-label uses ignore FDA approved indications in favor of whatever Pharma wants to say to sell a drug.

3) In China, GSK was charged with being even more brazen—employing a network of 700 middlemen and travel agencies and sex workers to convince doctors to prescribe its drugs.

4) Johnson & Johnson wined and dined Texas Medicaid officials, charged state authorities, treating them to trips, perks and honoraria to get its expensive antipsychotic drug Risperdal preferred status on the state formulary where it would be paid for by taxpayers. (Taxpayers were also bilked by the Department of Veterans Affairs expenditure of $717 million on Risperdal only to discover the drug worked no better than a placebo.)

5) Bristol-Myers Squibb enticed doctors to prescribe its drugs with access to the Los Angeles Lakers and luxury box suites for their games, according to California regulators.

6) And, in keeping with the marketing free-for-all that has hooked so many Americans on opioid drugs, opioid makerVictory Pharma was charged with treating doctors to mortgage assistance and… lap dances.

Golf Trips Are Not the Only Way Pharma Pays Doctors

Doctors may not get to go to the Caribbean as they once did, but they make a huge amount of money from Pharma by giving speeches promoting its drugs. The speech-givers, who sit on Pharma’s speakers’ bureaus, are considered “key opinion leaders,” capable of convincing other doctors of a drug’s benefits so they will then prescribe the drug.

According to ProPublica, Sujata Narayan, a family medicine doctor practicing in Stanford, CA earned an astounding $43.9 million promoting drugs for Pharma. Karen Underwood, a pediatric critical care doctor in Scottsdale, AZ received a walloping $28 million. Moreover, hospitals are also awash in Pharma money with the City Of Hope National Medical Center receiving $361 million and the Cleveland Clinic Foundation $22 million.

Pharma also pays doctors to conduct studies of its drugs often paying them for each subject they recruit and winning their loyalty because they are then familiar with the drug after monitoring subjects on it. A huge Pfizer trial of the drug Neurontin was conducted just this way charged Carl Elliot in the New York Times: 772 study investigators were recruited so they would personally prescribe the drug once they were familiar with it. The study was not conducted to establish effectiveness and safety and the joke was on them—and the public.

Traditionally, Pharma also paid for Continuing Medical Education courses, or CME, that are required for doctors to keep their state licenses and sometimes their insurance. Since the Pharma subsidized CMEs were “free,” doctors saved money they would have spent to enroll in a real course but of course had to listen to a Pharma sales pitch as a captive audience, instead.

Until transparency laws, CME course materials did not even hide Pharma funding. For example, a 2008 course called “Bipolar disorder: individualizing treatment to improve patient outcomes, part 2” was unabashedly taught by teachers funded by Abbott, Eli Lilly, AstraZeneca; GlaxoSmithKline, Janssen, Novartis, Pfizer, Wyeth, Bristol-Myers Squibb, Shire and four more drug companies.

Pharma has also used CMEs for damage control when safety signals about a drug could tank sales. When dentists, oral surgeons and patients began seeing “jawbone death” from the popular bone drugs called bisphosphonates, Pharma told doctors in its free CMEs it was not the drugs but patients’ poor “hygiene” that was causing the serious and disfiguring side effect. Right. Seven years after hormone replacement therapy (HRT) was linked to increased risks of cancer, heart disease and stroke Pharma CMEs marketing HRT as if nothing had happened at Duke University, Penn State University and University of Oklahoma medical schools, the Cleveland Clinic and on Medscape.

Pharma funded CMEs also helped “disease awareness,” an insidious selling tactic. When Lilly’s antidepressant Cymbalta got FDA approval for use in fibromyalgia, Lilly gave nonprofits$3.9 million in CME grants to raise “awareness” of fibromyalgia. Have drug; need patients.

Defending Pharma Payments

Medical professionals have accused journalists of putting undue focus on Pharma payments, maintaining that it does not affect their prescribing and also that the world has bigger problems. New York University professor Lila E. Nachtigall, who received $124,000 from Pharma for speaking and other promotional fees, said “It kind of makes me laugh” that Pharma links are a concern, “with what goes on in the Senate.”

But journalists hew to a strict “no gifts” code themselves. According to the Reuters Handbook of Journalism, professional journalists do not accept “any payment, gift, service or benefit (whether in cash or in kind) offered by a news source or contact,” or “hospitality when there is no news value,” or travel “junkets.” Journalists must pay their own way on trips to maintain “accuracy, balance and the truth,” says Reuters. Other reputable news organization adhere to the same standards.

At medical conferences, doctors often show slides disclosing all the Pharma companies who pay them before segueing into their “objective” medical study. Imagine what would happen if a journalist disclosed financial payments from an entity or industry and then proceeded to “report” on it.

Free Lunches Still Common—and Sway Prescribing

In 2002, Pharma’s lobbying group PhRMA adopted a voluntary code discouraging free trips and tickets to the theater or sporting event for doctors. But the code still allows free meals. A recent study in JAMA Internal Medicine found that even a lowly, $20 meal resulted in more prescriptions for Pharma.

The study found doctors who received even one free meal were 70 percent more likely to prescribe the brand-name beta blocker Bystolic, 52 percent more likely to prescribe the brand-name ACE inhibitor Benicar, 118 percent more likely to prescribe the brand-name antidepressant Pristiq and 18 percent more likely to prescribe the brand-name statin Crestor. Preference for the drug linked to a free meal existed even though generic equivalents exist for all four drugs which significantly save patients and the health care system money. The study found that more than one free meal increased the likelihood of doctors prescribing the drugs with the exception of Pristiq, a “me-too” antidepressant with significant risks that was included in a legal settlement charging misrepresentation.

Of course doctors can take umbrage at the suggestion that they “can be bought for a hero or a slice of pizza,” said the study’s lead author R. Adams Dudley, a professor of medicine and health policy at the University of California, San Francisco. But “it is human nature for a doctor to reciprocate by listening to the pitch of a sales representative bearing free food or beverages.”

An editorial accompanying the JAMA Internal Medicine study said, “There are inherent tensions between the profits of health care companies, the independence of physicians and the integrity of our work, and the affordability of medical care. If drug and device manufacturers were to stop sending money to physicians for promotional speaking, meals and other activities without clear medical justifications and invest more in independent bona fide research on safety, effectiveness and affordability, our patients and the health care system would be better off.” It is an understatement.

Not only do we now know that even a free meal can affect prescribing decisions, three years after the Sunshine Act, more than half of US doctors were still enjoying free meals, gifts and outright payments from Pharma.

About the Author

Martha Rosenberg is a freelance journalist covering the pharmaceutical industry. 

This article (The Outrageous Ways Big Pharma Has Bribed Doctors to Shill Drugs) is re-printed here with permission from The Influence, a site covering the full spectrum of human relationships with drugs. Follow the Influence on Facebook and on Twitter.**

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