Glyphosate (Roundup) Carcinogenic In the Parts Per Trillion Range

June 17, 2013 | By | Reply More

RoundupSayer Ji, Green Med Info
Waking Times

An alarming new study finds that glyphosate, the active ingredient in Roundup weedkiller, is estrogenic and drives breast cancer cell proliferation in the parts-per-trillion range. Does this help explain the massive mammary tumors that the only long term animal feeding study on Roundup and GM corn ever performed recently found?

An alarming new study, accepted for publication in the journal Food and Chemical Toxicology last monthindicates that glyphosate, the world’s most widely used herbicide due to its widespread use in genetically engineered agriculture, is capable of driving estrogen receptor mediated breast cancer cell proliferation within the infinitesimal parts per trillion concentration range.[i]

The study, titled, “Glyphosate induces human breast cancer cells growth via estrogen receptors,” compared the effect of glyphosate on hormone-dependent and hormone-independent breast cancer cell lines, finding that glyphosate stimulates hormone-dependent cancer cell lines in what the study authors describe as “low and environmentally relevant concentrations.”

The results were broken down by the researchers as follows:

  • Glyphosate induces T47D, hormone dependent breast cancer cell growth.
  • The proliferative effect of glyphosate is mediated via estrogen receptors.
  • Glyphosate induces ERE [Estrogen Response Element]-transcription activity via estrogen receptors.
  • Glyphosate modulates the expression of E[strogen] R[eceptor] α and E[estrogen] R[eceptor]β in human breast cancer cells.

These effects indicate that glyphosate is a ‘xenoestrogen,’ capable of inducing Estrogen Response Elements (EREs) in a manner, slightly weaker but functionally similar to the most potent human estrogen Estradiol (E2).

More concerning is the discovery that infinitesimal glyphosate concentrations in the parts-per-trillion rage (10 to the minus 12) had proliferative (carcinogenic) effects on the studied T47D breast cancer cells line:

“In this study, we found that glyphosate at a log interval concentration ranging from 10-12 to 10-6 M increased the cell proliferation of a hormorne dependent breast cancer T47D cell…”

The researchers also discovered that the naturally occurring phytoestrogen in soybean known as genistein, produced “an additive estrogenic effect” when combined with glyphosate, raising the serious question as to whether GMO soybeans are contributing to the epidemic levels of breast cancer within countries like the US where they are consumed in relatively high quantities.

It should be noted that the concentrations used to determine the interactive effects of glyphosate and phytoestrogen genistein in this study were modeled “as in a real world situation” by using information obtained from studies that assayed the respective levels of genistein and glyphosate in GM soybeans, as well as human plasma and urine concentrations following their consumption and/or exposure.  For instance, glyphosate concentrations have been detected within human urine within the 0.1 – 233 parts per billion range on the lowest end, and an estimated systemic dose of 0.004 mg/kg on the high end.

The authors stated:

This finding should raise concern about the existence of more than one xenoestrogen such as phytoestrogen and contaminants in plant derived food which may be beneficial or harmful depending on the hormonal and pathological status of consumers. This study implied that the additive effect of glyphosate and genistein in postmenopausal woman may induce cancer cell growth. In this present in vitro study, we showed an estrogenicity of pure glyphosate. In summary, we found that glyphosate exhibited a weaker estrogenic activity than estradiol. Furthermore, this study demonstrated the additive estrogenic effects of glyphosate and genistein which implied that the use of glyphosate-contaminated soybean products as dietary supplements may pose a risk of breast cancer because of their potential additive estrogenicity.” [emphasis added]

This finding is relevant to virtually anyone who consumes genetically modified food today. GM crops, which are designed to survive glyphosate poisoning by being genetically engineered with ‘glyphosate-resistance” (i.e. RoundUp Ready), are universally contaminated with glyphosate and its toxic metabolite AMPA.  Furthermore, glyphosate pollution and exposure is now omnipresent, with one 2011 study finding glyphosate in 60-100% of all US air and rain samples tested, and another 2012 study finding that glyphosate widely contaminates groundwater, which is the water located beneath the ground surface, that supplies aquifers, wells and springs. It is therefore virtually impossible to hermetically seal yourself off from the growing global environmental threat by only consuming “certified organic” food. The time has come to face the fact that unless there is a systemic change in the way our GM, petrochemically-driven monocultured food production system operates, we will all experience a great deal of harm.

GM Food/Roundup Breast Cancer Link Already Firmly Established

This latest study is not the only compelling evidence that there is a Roundup-Breast Cancer link. In a previous article titled, “Will the GMO-Breast Cancer Link Be Pinkwashed Away?“, we addressed the disturbing implications of the first long-term GM and Roundup animal feeding study produced by Gilles-Éric Séralini’s research team last November, and which found that after 90 days (the temporal threshold beneath which all previous biotech industry funded GM food safety studies end) the animals began to show disturbing signs of systemic organ damage, failure and cancer. More pointedly, Séralini’s team observed that the animals developed massive, estrogen-dependent mammary tumors:

Suffering inducing euthanasia and deaths corresponded mostly in females to the development of large mammary tumors. These appeared to be clearly related to the various treatments when compared to the control groups. These tumors are generally known to be mostly estrogen-dependent (Harvell et al., 2000). We observed a strikingly marked induction of mammary tumors by R[roundup] alone, a major formulated pesticide, even at the very lowest dose administered. R[oundup] has been shown to disrupt aromatase which synthesizes estrogens (Richard et al., 2005)…  [pg. 9]“

Could the results of this latest study help explain the molecular mechanism behind this finding?

About the Author

Sayer Ji is an author, researcher, lecturer, and advisory board member of the National Health Federation.

He founded Greenmedinfo.com in 2008 in order to provide the world an open access, evidence-based resource supporting natural and integrative modalities. It is internationally recognized as the largest and most widely referenced health resource of its kind.

Resources:

[i] Siriporn Thongprakaisang, Apinya Thiantanawat, Nuchanart Rangkadilok, Tawit Suriyo, Jutamaad Satayavivad. Glyphosate induces human breast cancer cells growth via estrogen receptors.Food Chem Toxicol. 2013 Jun 8. Epub 2013 Jun 8. PMID: 23756170

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of WakingTimes or its staff.

~~ Help Waking Times to raise the vibration by sharing this article with the buttons below…

Tags: , , , , , , , , , , ,

Category: Agriculture, Body, Business, Community, Earth, Environment, Food, Self, Society

Leave a Reply

Must Watch Videos

The Influence Vedic Philosophy Had On Nikola Tesla’s Idea Of Free Energy

The Influence Vedic Philosophy Had On Nikola Tesla’s Idea Of Free Energy













Arjun Walia, Collective-Evolution
Waking Times

The Properties of Space

Science works best when in harmony with nature. If we put these two together, we can discover great technologies that can only come about when the consciousness of the planet is ready to embrace them. One example is “free energy,” also … More

July 29, 2014 | By | Reply More
Earth is Our Holy Land

Earth is Our Holy Land













Stephen Parato, Contributor
Waking Times

It’s become painfully obvious…

We’ve been getting played out for a long, long time; manipulated into the illusion of separation. We’re deviating from our essence of love, succumbing to fear, allowing ourselves to get dragged into senseless conflict and destroying our beautiful planet.

“Just look More

July 29, 2014 | By | 3 Replies More
The Awakening – Clash of Civilizations

The Awakening – Clash of Civilizations













Zen Gardner, Guest
Waking Times

Despite the furious efforts of the world’s Machiavellian destroyers, humanity is waking up. We’re seeing significant progress in exposing the ongoing brutal Gaza extermination, the mass revelation of chemtrails and other neo-scientific incursions, the disastrous effects of EMFs of every source, GMO food manipulation, … More

July 23, 2014 | By | 4 Replies More
Raw Milk Versus Pasteurized—Which Is Safer?

Raw Milk Versus Pasteurized—Which Is Safer?













Dr. Mercola
Waking Times

The United States lags far behind many other nations when it comes to food safety and nutritional recommendations, and this is perhaps particularly true when it comes to raw milk.

The fact is, large dairy farmers operating under the factory farm model simply cannot produce raw … More

July 23, 2014 | By | 2 Replies More
Toxic Hot Seat—What You Don’t Know About Flame Retardant Chemicals Can Hurt You

Toxic Hot Seat—What You Don’t Know About Flame Retardant Chemicals Can Hurt You













Dr. Mercola
Waking Times

Fear of fire is primal. No one wants to burn to death. This is undoubtedly why it’s so difficult to repeal laws relating to the use of fire retardant chemicals—even though experiments show they do not work… and worse, they’re actually exposing you to … More

July 21, 2014 | By | 1 Reply More

Activism Works

Seizing Control of Our Destinies

Seizing Control of Our Destinies













Julian Rose, Contributor
Waking Times

In 1381, at a time of great repression for the British agricultural work force, an extraordinary people’s revolutionary named Wat Tyler sprang to his feet and announced, “England should be a nation of self governing communities,” to which he added, “ No lord shall exercise … More

July 28, 2014 | By | 4 Replies More
Triumph For Citizens in Florida As Hughes Oil Company Drops Fracking Project

Triumph For Citizens in Florida As Hughes Oil Company Drops Fracking Project













Julie Dermansky, DeSmogBlog
Waking Times

On Friday morning, Dan A. Hughes Oil Company and the Collier Resources Company agreed to terminate their lease agreement, with the exception of the Collier Hogan 20-3H well, next to the Corkscrew Swamp Sanctuary in Naples, Florida.

Hughes Oil dropped its plans to drill … More

July 14, 2014 | By | 1 Reply More
A Forgotten Community in New Orleans: Life on a Superfund Site

A Forgotten Community in New Orleans: Life on a Superfund Site













Julie Dermansky, DeSmogBlog
Waking Times

Shannon Rainey lives in a house that was built on top of a Superfund site in the Upper Ninth Ward of New Orleans.

“I bought my house when I was 25, and thirty years later, I still can’t get out,” she told DeSmogBlog.

Rainey’s … More

June 23, 2014 | By | 1 Reply More
Wave of GMO Labeling Victories Emboldens Movement to Take Back Food Democracy

Wave of GMO Labeling Victories Emboldens Movement to Take Back Food Democracy













Michele Simon, EcoWatch
Waking Times

The East Coast has been getting most of the attention lately on the state by state effort to label genetically-engineered food. Vermont recently passed a bill and New York State’s bill is now moving. But let’s not forget about the western states, which are also … More

June 11, 2014 | By | 1 Reply More
Monsanto’s Roundup Found in 75% of Air and Rain Samples

Monsanto’s Roundup Found in 75% of Air and Rain Samples













John Deike, EcoWatch
Waking Times

A new U.S. Geological Survey has concluded that pesticides can be found in, well, just about anything.

Roundup herbicide, Monsanto’s flagship weed killer, was present in 75 percent of air and rainfall test samples, according to the study, which focused on Mississippi’s highly fertile … More

May 27, 2014 | By | 2 Replies More