The Science of Psilocybin and the Ego-centric Brain

November 1, 2012 | By | 4 Replies More

Anna Hunt, Contributing Writer
Waking Times 

A recent study conducted by Carhart-Harrisa et al., and published in the PNAS scientific journal, offers a glimpse of the effects of the drug psilocybin, which can be found in “magic” mushrooms, on the human brain. The study monitored the brains of 30 individuals using functional magnetic resonance imaging (fMRI) after the participants were injected with a dose of psilocybin. The findings were discussed in a recent article in Psychology Today:

The researchers were surprised to discover that drug effects were associated with decreases in activity in a number of key brain areas, rather than the expected increase. This finding has led to speculations about the relationship between brain activity and mystical states experienced under psychedelic drugs. However, the actual implications of the study’s findings are far from clear.

The fMRI scans revealed that brain blood flow decreased following the psilocybin injection, when compared to activity when a saline injection was given, which indicates that psilocybin reduces activity in the brain.

Activity in areas regarded as important network hubs that maintain the connectivity of the various areas of the brain showed the most consistent deactivation. These areas are known as the medial prefrontal cortex (mPFC) and the posterior cingulate cortex (PCC).

These two areas appear to play important roles in the regulation of self-awareness as they are particularly activated when people are asked to think about themselves.

The intensity of the alterations of conscious experience reported by the volunteers was proportional to the decrease in brain activity. That is, the more brain activity decreased, the more vivid the “trip” experienced.  

In normal conditions, the mPFC and PCC areas of the brain typically show a considerably higher activity than other parts. The study’s authors aligned their findings with Aldous Huxley’s assessment of the human brain, “The mind is a reducing valve.”(The Doors of Perception)

“[Aldous Huxley] compared the brain to a ‘reducing valve’. In ordinary perception, the senses send an overwhelming flood of information to the brain, which the brain then filters down to a trickle it can manage for the purpose of survival in a highly competitive world. Man has become so rational, so utilitarian, that the trickle becomes most pale and thin. It is efficient, for mere survival, but it screens out the most wondrous part of man’s potential experience without his even knowing it. We’re shut off from our own world.” – Tom Wolfe, The Electric Kool-Aid Acid Test

Carhart-Harrisa et al. believe that the “mind expanding” effect that one would experience when consuming psychedelic drugs is a result of the reduced brain activity in the mPFC and PCC areas of the brain, no longer shielding the individual from the world around us:

“The results [of the study] seem to imply that a lot of brain activity is actually dedicated to keeping the world very stable and ordinary and familiar and unsurprising,” says Robin Carhart-Harris

In the recent years, many new studies have been conducted in an attempt to understand the effectiveness of psilocybin in the treatment of depression, post-traumatic stress disorder and anxiety, and in helping terminally-ill patients come to terms with dying. Carhart-Harris has stated, “Probably the most reliable finding in depression is that the mPFC is overactive.” (source: Time Magazine) Carhart-Harris et al.’s newest study may create a foundation for additional research into the area of treating depression with psilocybin in order to pacify the brain.

Sources:

http://healthland.time.com/2012/01/24/magic-mushrooms-expand-the-mind-by-dampening-brain-activity/#ixzz2AuSs2bMo

http://www.pnas.org/content/early/2012/01/17/1119598109.full.pdf

http://www.psychologytoday.com/blog/unique-everybody-else/201210/psilocybin-anxiety-and-depression-in-cancer

http://www.psychologytoday.com/blog/unique-everybody-else/201210/psilocybin-and-brain-function

About the Author

Anna Hunt is a writer, entrepreneur and yoga instructor. She enjoys raising her children and being a voice for optimal human health and wellness. Read more of her excellent articles here, and visit her website PuraVidaYogaVacations.com.

This article is offered under Creative Commons license. It’s okay to republish it anywhere as long as attribution bio is included and all links remain intact.

~~ Help Waking Times to raise the vibration by sharing this article with the buttons below…

Tags: , , , , , , ,

Category: All Original Articles, Anna Hunt, Body, Consciousness, Contributors, Healthcare, Mind, Self, Society, Uncategorized

Comments (4)

Trackback URL | Comments RSS Feed

  1. Ivor says:

    The route of administration e.g. eating as opposed to an injection has a profound effect .. this is well known in pharmaceutical circles it can be easily confirmed by experimenting on oneself.

    Also one can attain those spaces by meditation.

    Thank you for the article and how nice that such matters now seem to be gathering in scientific frequency.

  2. Max says:

    I have Believed for many years that the organic natural remedy of psilocybin Is far more effective taken annually instead of months and years of current drug intake like Paxil , Wellbutrin and many others that supposedly fight depression. Injection seems to take away from the natural experience and ability to come on gradually to get the full affect pf the magic mushroom .

  3. Chris says:

    I wonder what role the mPFC and PCC play in depersonalization disorder? I was diagnosed with non-drug induced depersonalization at 15 years old. Doctors say it was likely due to all the stress I was dealing with at that time. I am now 30 and depersonalization still plays an unfortunately significant role in my life.

    However, when I was about 24 years old, I consumed psilocybe cubensis and was subsequently immersed into a world of such utterly indescribable hyper-reality, that I was able to see things even more clearly than I had before falling into this cursed stated of mind that is depersonalization.

    I really hope more opportunities become available for people to investigate the possible therapeutic benefits of psychedelics like psilocybin. I’d be extremely grateful to have the opportunity to go there again – to feel like I really exist.

Leave a Reply

Must Watch Videos

NASA Brings Scientists & Theologians Together To Prepare World For Extraterrestrial Contact

NASA Brings Scientists & Theologians Together To Prepare World For Extraterrestrial Contact













Arjun Walia, Collective-Evolution
Waking Times

A couple of months ago top U.S. astronomers gathered in front of congress to let them know that extraterrestrial life exists without question. Their main argument was the size of the universe, emphasizing that there are trillions of stars out there, with one in every … More

September 26, 2014 | By | 13 Replies More
Mom Says NO to School System Intimidation

Mom Says NO to School System Intimidation













Heather Callaghan, Contributor
Waking Times

And Common Purpose, and the threat of Social Services…

This British mum smacks down the punishing culture of the public school system . She gives a chilling account of what happened when her son was given confusing commands, humiliated in front of class, brought to … More

September 26, 2014 | By | 2 Replies More
Money and the Myth of Freedom

Money and the Myth of Freedom













Gregg Prescott, M.S., In5D Guest
Waking Times

What if EVERYONE was wealthy beyond their wildest dreams and how would that affect our perceived “freedom”?

I often use an analogy of freedom as a man walking his dog.  The man is the government, you are the dog and the leash is … More

September 23, 2014 | By | 4 Replies More
6 Notoriously Misleading Food Terms Used to Trick Consumers

6 Notoriously Misleading Food Terms Used to Trick Consumers













Arjun Walia, Collective-Evolution
Waking Times

Our modern day food industry has become quite the debacle, with chemicals being sprayed all over our fruits and vegetables, to genetically modifying to processed food. As a result, the world has seen a large resistance to modern day food practices, and the resistance continues … More

September 23, 2014 | By | 1 Reply More
Mysterious Virus Spreading Across U.S. and Canada And Primarily Affecting Vaccinated Children

Mysterious Virus Spreading Across U.S. and Canada And Primarily Affecting Vaccinated Children













Dave Mihalovic, Prevent Disease
Waking Times

It’s being considered a severe respiratory virus known as EV-D68. It hits hard and fast and has already created an outbreak in Colorado, Missouri, Utah, Kansas, Illinois, Ohio, and four more states in the Midwest. It has also crossed over the Canada with confirmed … More

September 23, 2014 | By | 2 Replies More

Activism Works

Peace Through Synchronized Global Meditation

Peace Through Synchronized Global Meditation













Lance Schuttler, Personable Media
Waking Times

We live in a world today where the idea of group power is being rekindled and where it’s momentum is gathering. Humanity as a whole is remembering that it is thoughts and actions of kindness, honesty and equality for all that create positive change.… More

September 21, 2014 | By | 3 Replies More
7 Ways Cannabis Legalization Has Already Benefited Colorado

7 Ways Cannabis Legalization Has Already Benefited Colorado













Jeff Roberts, Collective-Evolution
Waking Times

January 1st 2014 saw the opening of the very first cannabis shop in Colorado as the cultivation, manufacture and sale of the controversial plant became fully legalized. Since then, the state has seen a lot of promising results.

Laura Pegram of Drugpolicy.org wrote in her … More

September 16, 2014 | By | Reply More
Sweden Recycling 99 Percent Of Garbage, Edging Closer To Zero-Waste

Sweden Recycling 99 Percent Of Garbage, Edging Closer To Zero-Waste













April McCarthy, Prevent Disease
Waking Times

There’s a revolution happening in Sweden right now. Dubbed the “recycling revolution,” the Scandinavian country now recycles 99 percent of their garbage, edging closer to a zero-waste lifestyle, nationwide.

Wouldn’t it be great if no household waste was wasted? If each and every item … More

September 4, 2014 | By | 6 Replies More
Food as Medicine: How One Hospital Is Using Organic Produce to Help Heal Patients

Food as Medicine: How One Hospital Is Using Organic Produce to Help Heal Patients













Coach Mark Smallwood, EcoWatch
Waking Times

In 431 B.C. Hippocrates said, “Let food be thy medicine and medicine be thy food”

More than 2500 years later, we are inundated with advertisements boasting the latest, greatest cure-all super drug. From a young age, we learn that it doesn’t matter how or … More

August 23, 2014 | By | 5 Replies More
As Keystone XL Dominoes Fall, Time to Arrest Tar Sands Industry

As Keystone XL Dominoes Fall, Time to Arrest Tar Sands Industry













, EcoWatch
Waking Times

We’ve got this.

Thanks to the courageous and indefatigable efforts of pipeline fighters everywhere, the tide has finally turned on Keystone XL. As it becomes increasingly clear that Keystone XL’s northern leg is not going through, it is time to set our sights … More

August 4, 2014 | By | 2 Replies More